A massive nationwide vaccination effort has begun in the U.S. as hospitals continue filling up with COVID-19 patients fighting for their lives. The nation has surpassed 300,00 deaths from the virus. Dr. Uché Blackstock joins CBSN to talk about the Pfizer and Moderna vaccines and what Americans need to do to fight the pandemic in the meantime. Source

Melania Trump’s fourth and final festive visit as first lady on Tuesday looked a little different from past seasons. Source

President-elect Joe Biden attacks Republicans as Democrats seek control of the Senate via the Georgia runoffs. Ed O’Keefe reports. Source

The U.S. is on the verge of having two vaccines to fight the coronavirus, giving hope to frontline workers. Mola Lenghi reports. Source

New video has surfaced in the killing of Ahmaud Arbery, who was gunned down while jogging in February. Omar Villafranca has the latest. Source

Here’s a look at the top stories making headlines on the “CBS Evening News with Norah O’Donnell.” Source

The FDA said the Moderna vaccine​ overall is 94.5% effective and 100% effective in people 65 and over. Source

Nine-year-old Abby Hucker of Massachusetts watches the news to help cope with the pandemic. Norah O’Donnell surprises the aspiring journalist. Source

President-elect Joe Biden returned to the campaign trail in Atlanta on Tuesday to speak at a rally on behalf of Democratic Senate candidates Jon Ossoff and Raphael Warnock. The outcome of Georgia’s Senate runoff elections will determine which party controls the chamber during Mr. Biden’s first term. CBSN political reporter Caitlin Huey-Burns joins CBSN’s “Red & Blue” from Atlanta with the details. Source

William “Roddie” Bryan told police he tried to “block” Ahmaud Arbery while he was being chased by two other men. Source